The Branching Point in Diaminopimelic Acid Synthesis
نویسندگان
چکیده
منابع مشابه
The enzymatic synthesis of diaminopimelic acid.
a-e-Diaminopimelic acid was discovered by Work in 1949 (1) as a constituent of Corynebacterium diphtheriae. It was also described as occurring in a peptide fraction obtained from Mycobacterium tuberculosis by Asselineau et al. (2). Since the time of these reports distribution of the amino acid has been systematically investigated by Work (3). She found the compound to be generally present in th...
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This article reviews synthesis of 2,6-diaminopimelic acid, an important amino acid biosynthesized by bacteria and higher plants. A number of peptidoglycan fragments containing the diaminopimelic acid (DAP) residue exhibit antitumor and/or immunostimulant activity. DAP is a versatile building block of many natural and synthetic compounds with a number of potential medicinal applications. The syn...
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In order to facilitate the elucidation of the remaining undetermined steps in diaminopimelic acid and lysine biosynthesis, mutants blocked in the pathway between aspartic semialdehyde and a-N-succinyl-e-ket.opimelic acid were sought. A mutant (M-203) with a requirement for diaminopimelate and lysine was obtained. An examination of the enzymatic composition of the extract prepared from the mutan...
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Diaminopimelic acid was found to be a component of the cell wall of the Legionnaires disease bacterium, thus providing additional evidence that the organism is a bacterium. The presence of this amino acid was determined by gas-liquid chromatography and confirmed by gas chromatography-mass spectrometry.
متن کاملThe stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase.
Aziridine analogues of diaminopimelic acid (DAP) have been prepared stereoselectively for the first time and evaluated as inhibitors of DAP epimerase. (2R,3S,3'S)-3-(3'-Aminopropane)aziridine-2,3'-dicarboxylate was synthesised and shown to be a reversible inhibitor of DAP epimerase with an IC(50) value of 2.88 mM. (2S,4S)- and (2S,4R)-2-(4-Amino-4-carboxybutyl)aziridine-2-carboxylic acid (ll-az...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1962
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)93947-5